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-synuclein, which can be a most important element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) worry, recommend that dysfunction of your intracellular proteinase devices, for instance ubiquitin-proteasome procedure or lysosomal system, which gets rid of u